Metabolism and Excretion of Intravenous, Radio-Labeled Amisulpride in Healthy, Adult Volunteers.

ABSTRACT:

Purpose

Intravenous amisulpride, a dopamine D₂/D₃ antagonist, has recently been shown in trials to be an effective antiemetic at low doses. This study was conducted to investigate the metabolism and elimination of a single dose of intravenous ¹⁴C-labeled amisulpride in healthy, adult volunteers.

Patients and methods

Six healthy male volunteers aged 18-65 years were given a single 10 mg dose of ¹⁴C-labeled amisulpride containing not more than 1.8 MBq of radioactivity, infused over 4 mins. Concentrations of amisulpride and total radioactivity were measured in plasma, whole blood, urine and feces at various time points up to 168 hrs after dosing. Metabolites detected in plasma, urine and feces were characterized using liquid chromatog

SUBMITTER: Fox GM 

PROVIDER: S-EPMC6896931 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature