Epigenome-wide association of father's smoking with offspring DNA methylation: a hypothesis-generating study.

ABSTRACT: Epidemiological studies suggest that father's smoking might influence their future children's health, but few studies have addressed whether paternal line effects might be related to altered DNA methylation patterns in the offspring. To investigate a potential association between fathers' smoking exposures and offspring DNA methylation using epigenome-wide association studies. We used data from 195 males and females (11-54 years) participating in two population-based cohorts. DNA methylation was quantified in whole blood using Illumina Infinium MethylationEPIC Beadchip. Comb-p was used to analyse differentially methylated regions (DMRs). Robust multivariate linear models, adjusted for personal/maternal smoking and cell-type proportion, were used to analyse offspring differentially associat

SUBMITTER: Morkve Knudsen GT 

PROVIDER: S-EPMC6896979 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature