Memory Performance Correlates of Hippocampal Subfield Volume in Mild Cognitive Impairment Subtype.

ABSTRACT: The increased understanding that neuropathology begins decades before symptom onset, has led to the conceptualization and widespread utilization of Mild Cognitive Impairment (MCI) as an important transitional state between healthy aging and dementia. Further subcategorization to MCI subtype has led to more distinct prognoses and it is widely considered that amnestic and non-amnestic MCI (aMCI, naMCI) likely have distinct pathophysiologies. Yet, accurately classification remains contentious. Here, we differentiate hippocampal subfield volume between subtypes, diagnosed according to stringent clinical consensus criteria, where aMCI is characterized based on deficits in delayed recall (rather than encoding). We then identify memory performance correlates to subfield volume and associations wi

SUBMITTER: Broadhouse KM 

PROVIDER: S-EPMC6897308 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature