Unknown

Dataset Information

0

The chemical synthesis of human milk oligosaccharides: Lacto-N-tetraose (Galβ1→3GlcNAcβ1→3Galβ1→4Glc).

ABSTRACT: The total chemical synthesis of lacto-N-tetraose (LNT) has been completed using both convergent and linear strategies. Similarly to that of our previous HMO syntheses, the donor-acceptor protecting-leaving group combinations were found to be of paramount significance to achieving successful glycosylations and minimizing side reactions.

SUBMITTER: Bandara MD 

PROVIDER: S-EPMC6897367 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The chemical synthesis of human milk oligosaccharides: Lacto-N-tetraose (Galβ1→3GlcNAcβ1→3Galβ1→4Glc).

Bandara Mithila D MD   Stine Keith J KJ   Demchenko Alexei V AV  

Carbohydrate research 20190925

The total chemical synthesis of lacto-N-tetraose (LNT) has been completed using both convergent and linear strategies. Similarly to that of our previous HMO syntheses, the donor-acceptor protecting-leaving group combinations were found to be of paramount significance to achieving successful glycosylations and minimizing side reactions. ...[more]

Similar Datasets

Unknown The chemical synthesis of human milk oligosaccharides: Lacto-N-neotetraose (Galβ1→4GlcNAcβ1→3Galβ1→4Glc).
| S-EPMC6717531 | biostudies-literature
Unknown Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)2 3,6Galβ1 → 4Glc.
| S-EPMC7658587 | biostudies-literature
Unknown Chemical Synthesis of Human Milk Oligosaccharides: Lacto-<i>N</i>-hexaose Galβ1→3GlcNAcβ1→3 [Galβ1→4GlcNAcβ1→6] Galβ1→4Glc.
| S-EPMC8114087 | biostudies-literature
Unknown Bifidobacterium breve UCC2003 metabolises the human milk oligosaccharides lacto-N-tetraose and lacto-N-neo-tetraose through overlapping, yet distinct pathways.
| S-EPMC5144078 | biostudies-literature
Unknown Chemical Synthesis of Human Milk Oligosaccharides: para-Lacto-N-hexaose and para-Lacto-N-neohexaose.
| S-EPMC11370726 | biostudies-literature
Unknown Chemical Synthesis of Two Fucosylated Human Milk Oligosaccharides: 3-Fucosyllactose and Lacto-N-fucopentaose V.
| S-EPMC12368511 | biostudies-literature
Unknown Chemical Synthesis of Human Milk Oligosaccharides: Sialyllacto-&lt;i&gt;N&lt;/i&gt;-Tetraose a (LSTa).
| S-EPMC12813665 | biostudies-literature
Unknown Infant-gut associated Bifidobacterium dentium strains utilize the galactose moiety and release lacto-N-triose from the human milk oligosaccharides lacto-N-tetraose and lacto-N-neotetraose.
| S-EPMC8639736 | biostudies-literature
Unknown Synthesis of lacto-N-tetraose.
| S-EPMC6167749 | biostudies-literature
Unknown Inefficient Metabolism of the Human Milk Oligosaccharides Lacto-<i>N</i>-tetraose and Lacto-<i>N</i>-neotetraose Shifts <i>Bifidobacterium longum</i> subsp. <i>infantis</i> Physiology.
| S-EPMC5989456 | biostudies-literature