Onset of neonatal locomotor behavior and the mechanical development of Achilles and tail tendons.

ABSTRACT: Tendon tissue engineering approaches are challenged by a limited understanding of the role mechanical loading plays in normal tendon development. We propose that the increased loading that developing postnatal tendons experience with the onset of locomotor behavior impacts tendon formation. The objective of this study was to assess the onset of spontaneous weight-bearing locomotion in postnatal day (P) 1, 5, and 10 rats, and characterize the relationship between locomotion and the mechanical development of weight-bearing and non-weight-bearing tendons. Movement was video recorded and scored to determine non-weight-bearing, partial weight-bearing, and full weight-bearing locomotor behavior at P1, P5, and P10. Achilles tendons, as weight-bearing tendons, and tail tendons, as non-weight-beari

SUBMITTER: Theodossiou SK 

PROVIDER: S-EPMC6897371 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature