Conservation and global distribution of non-canonical antigens in Enterotoxigenic Escherichia coli.

ABSTRACT:

Background

Enterotoxigenic Escherichia coli (ETEC) cause significant diarrheal morbidity and mortality in children of resource-limited regions, warranting development of effective vaccine strategies. Genetic diversity of the ETEC pathovar has impeded development of broadly protective vaccines centered on the classical canonical antigens, the colonization factors and heat-labile toxin. Two non-canonical ETEC antigens, the EtpA adhesin, and the EatA mucinase are immunogenic in humans and protective in animal models. To foster rational vaccine design that complements existing strategies, we examined the distribution and molecular conservation of these antigens in a diverse population of ETEC isolates.

Methods

Geographically diverse ETEC isolates (n = 1159) were interrogated by

SUBMITTER: Kuhlmann FM 

PROVIDER: S-EPMC6897418 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature