A STELLA simulation model for in vitro dissolution testing of respirable size particles.

ABSTRACT: In vitro dissolution testing is a useful quality control tool to discriminate the formulations and to approximate the in vivo drug release profiles. A dissolution apparatus has been custom-made for dissolution testing of dry powder formulations in a small volume of stationary medium (25 μL spread over 4.91 cm² area i.e. ~50 μm thick). To understand the system and predict the key parameters which influence the dissolution of respirable size particles, a simulation model was constructed using STELLA modeling software. Using this model, the permeation (dissolution followed by diffusion through the membrane) of two anti-tubercular drugs of differing solubilities, moxifloxacin (17.68 ± 0.85 mg mL^-1) and ethionamide (0.46 ± 0.02 mg mL^-1), from the respirable size

SUBMITTER: Eedara BB 

PROVIDER: S-EPMC6898627 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature