Association of childhood traumatization and neuropsychiatric outcomes with altered plasma micro RNA-levels.

ABSTRACT: Childhood traumatization (CT) is associated with the development of several neuropsychiatric disorders in later life. Experimental data in animals and observational data in humans revealed evidence for biological alterations in response to CT that may contribute to its long-term consequences. This includes epigenetic changes in miRNA levels that contribute to complex alterations of gene expression. We investigated the association between CT and 121 miRNAs in a target sample of N = 150 subjects from the general population and patients from the Department of Psychiatry. We hypothesized that CT exhibits a long-term effect on miRNA plasma levels. We supported our findings using bioinformatics tools and databases. Among the 121 miRNAs 22 were nominally significantly associated with CT and four

SUBMITTER: Van der Auwera S 

PROVIDER: S-EPMC6898678 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature