Inhibitory Control Deficits Associated with Upregulation of CB₁R in the HIV-1 Tat Transgenic Mouse Model of Hand.

ABSTRACT: In the era of combined antiretroviral therapy, HIV-1 infected individuals are living longer lives; however, longevity is met with an increasing number of HIV-1 associated neurocognitive disorders (HAND) diagnoses. The transactivator of transcription (Tat) is known to mediate the neurotoxic effects in HAND by acting directly on neurons and also indirectly via its actions on glia. The Go/No-Go (GNG) task was used to examine HAND in the Tat transgenic mouse model. The GNG task involves subjects discriminating between two stimuli sets in order to determine whether or not to inhibit a previously trained response. Data reveal inhibitory control deficits in female Tat(+) mice (p = .048) and an upregulation of cannabinoid type 1 receptors (CB₁R) in the infralimbic (IL) cortex in the sam

SUBMITTER: Jacobs IR 

PROVIDER: S-EPMC6898753 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature