The Association Between Low-Density Lipoprotein Cholesterol and Incident Atherosclerotic Cardiovascular Disease in Older Adults: Results From the National Institutes of Health Pooled Cohorts.

ABSTRACT:

Background/objectives

Elevated low-density lipoprotein cholesterol (LDL-C) in early adulthood is associated with increased risk of atherosclerotic cardiovascular disease (ASCVD). The strength of the association between LDL-C and ASCVD among older adults, however, is less understood.

Design

We examined individual-level cohort data from the National Institutes of Health Pooled Cohorts (Framingham Study, Framingham Offspring Study, Multi-Ethnic Study of Atherosclerosis, and Cardiovascular Health Study), which prospectively measured CVD risk factors and incident disease.

Setting

Prospective cohort study.

Participants

Adults, aged 75 years or older, free of ASCVD.

Measurements

We evaluated the associations between LDL-C and incident ASCVD (stroke, myocardial

SUBMITTER: Nanna MG 

PROVIDER: S-EPMC6898756 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature