Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells.

ABSTRACT: Intermediary metabolism in cancer cells is regulated by diverse cell-autonomous processes, including signal transduction and gene expression patterns, arising from specific oncogenotypes and cell lineages. Although it is well established that metabolic reprogramming is a hallmark of cancer, we lack a full view of the diversity of metabolic programs in cancer cells and an unbiased assessment of the associations between metabolic pathway preferences and other cell-autonomous processes. Here, we quantified metabolic features, mostly from the ¹³C enrichment of molecules from central carbon metabolism, in over 80 non-small cell lung cancer (NSCLC) cell lines cultured under identical conditions. Because these cell lines were extensively annotated for oncogenotype, gene expression, pro

SUBMITTER: Chen PH 

PROVIDER: S-EPMC6898782 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature