Prospective virome analyses in young children at increased genetic risk for type 1 diabetes.

ABSTRACT: Viruses are implicated in autoimmune destruction of pancreatic islet β cells, which results in insulin deficiency and type 1 diabetes (T1D)^1-4. Certain enteroviruses can infect β cells in vitro⁵, have been detected in the pancreatic islets of patients with T1D⁶ and have shown an association with T1D in meta-analyses⁴. However, establishing consistency in findings across studies has proven difficult. Obstacles to convincingly linking RNA viruses to islet autoimmunity may be attributed to rapid viral mutation rates, the cyclical periodicity of viruses⁷ and the selection of variants with altered pathogenicity and ability to spread in populations. β cells strongly express cell-surface coxsackie and adenovirus receptor (CXADR) genes, which

SUBMITTER: Vehik K 

PROVIDER: S-EPMC6898786 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature