Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis.

ABSTRACT:

Background

Recent studies of cortical pathology in secondary progressive multiple sclerosis have shown that a more severe clinical course and the presence of extended subpial grey matter lesions with significant neuronal/glial loss and microglial activation are associated with meningeal inflammation, including the presence of lymphoid-like structures in the subarachnoid space in a proportion of cases.

Methods

To investigate the molecular consequences of pro-inflammatory and cytotoxic molecules diffusing from the meninges into the underlying grey matter, we carried out gene expression profiling analysis of the motor cortex from 20 post-mortem multiple sclerosis brains with and without substantial meningeal inflammation and 10 non-neurological controls.

Results

Gene exp

SUBMITTER: Magliozzi R 

PROVIDER: S-EPMC6898969 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature