Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses.

ABSTRACT: The maintenance of mitochondrial respiratory function and homeostasis is essential to human health. Here, we identify condensin II subunits as novel regulators of mitochondrial respiration and mitochondrial stress responses. Condensin II is present in the nucleus and cytoplasm. While the effects of condensin II depletion on nuclear genome organization are well studied, the effects on essential cytoplasmic and metabolic processes are not as well understood. Excitingly, we observe that condensin II chromosome-associated protein (CAP) subunits individually localize to different regions of mitochondria, suggesting possible mitochondrial-specific functions independent from those mediated by the canonical condensin II holocomplex. Changes in cellular ATP levels and mitochondrial respiration are

SUBMITTER: Deutschman E 

PROVIDER: S-EPMC6899004 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature