<i>Nanog</i> regulates <i>Pou3f1</i> expression at the exit from pluripotency during gastrulation.

ABSTRACT: Pluripotency is regulated by a network of transcription factors that maintain early embryonic cells in an undifferentiated state while allowing them to proliferate. NANOG is a critical factor for maintaining pluripotency and its role in primordial germ cell differentiation has been well described. However, Nanog is expressed during gastrulation across all the posterior epiblast, and only later in development is its expression restricted to primordial germ cells. In this work, we unveiled a previously unknown mechanism by which Nanog specifically represses genes involved in anterior epiblast lineage. Analysis of transcriptional data from both embryonic stem cells and gastrulating mouse embryos revealed Pou3f1 expression to be negatively correlated with that of Nanog<

SUBMITTER: Barral A 

PROVIDER: S-EPMC6899006 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature