Scribble and Discs-large direct initial assembly and positioning of adherens junctions during the establishment of apical-basal polarity.

ABSTRACT: Apical-basal polarity is a fundamental property of animal tissues. Drosophila embryos provide an outstanding model for defining mechanisms that initiate and maintain polarity. Polarity is initiated during cellularization, when cell-cell adherens junctions are positioned at the future boundary of apical and basolateral domains. Polarity maintenance then involves complementary and antagonistic interplay between apical and basal polarity complexes. The Scribble/Dlg module is well-known for promoting basolateral identity during polarity maintenance. Here, we report a surprising role for Scribble/Dlg in polarity initiation, placing it near the top of the network-positioning adherens junctions. Scribble and Dlg are enriched in nascent adherens junctions, are essential for adherens junction posit

SUBMITTER: Bonello TT 

PROVIDER: S-EPMC6899021 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature