Molecular profiling of stem cell-like female germ line cells in Drosophila delineates networks important for stemness and differentiation.

ABSTRACT: Stem cells can self-renew and produce daughter cells destined for differentiation. The precise control of the balance between these two outcomes is essential to ensure tissue homeostasis and to prevent uncontrolled proliferation resulting in tumor formation. As self-renewal and differentiation are likely to be controlled by different gene expression programs, unraveling the underlying gene regulatory networks is crucial for understanding the molecular logic of this system. In this study, we have characterized by next generation RNA sequencing (RNA-seq) the transcriptome of germline stem cell (GSC)-like cells isolated from bag of marbles (bam) mutant Drosophila ovaries and compared it to the transcriptome of germ line cells isolated from wild-type ovaries. We have compl

SUBMITTER: Tiwari MD 

PROVIDER: S-EPMC6899027 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature