Molecular Epidemiological Insights into Colistin-Resistant and Carbapenemases-Producing Clinical Klebsiella pneumoniae Isolates.

ABSTRACT:

Purpose

Carbapenemases-producing Klebsiella pneumoniae are challenging antimicrobial therapy of hospitalised patients, which is further complicated by colistin resistance. This study describes molecular epidemiological insights into colistin-resistant and carbapenemases-producing clinical K. pneumoniae.

Patients and methods

Cultures collected from 26 hospitalised patients during 2014-2017 in the main hospital in Molise Region, central Italy, were characterized. The minimum inhibitory concentration for 19 antibiotics was determined, including carbapenems and colistin. Prevalence of resistance-associated genes was investigated through PCR, detecting bla _KPC, bla _GES, bla _VIM, bla _IMP, bla<

SUBMITTER: Di Tella D 

PROVIDER: S-EPMC6899070 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature