Association of IRAK1 Gene Polymorphism rs3027898 With Papillary Cancer Restricted to the Thyroid Gland: A Pilot Study.

ABSTRACT:

Background/aim

The incidence of thyroid cancer has increased predominantly due to an increase in papillary thyroid cancer (PTC). Alteration of toll-like receptor function has been reported to play a crucial role in carcinogenesis. The aim of the present study was to investigate predisposition to PTC associated with genetic markers of toll-like receptor and interleukin-1 receptor pathways involving nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-ĸB) stimulation. Specifically, the study focused on the following genes: interleukin-1 receptor-associated kinase 1 (IRAK1, rs3027898), NF-ĸB inhibitor alpha (NFKBIA, rs696), NF-ĸB subunit 1 (NFKB1, rs28362491), and microRNA-146a (miR-146a, rs2910164).

Patients and methods

Forty-eight unrelated patients with papilla

SUBMITTER: Chatzikyriakidou A 

PROVIDER: S-EPMC6899100 | biostudies-literature | 2019 Nov-Dec

REPOSITORIES: biostudies-literature