Genome-wide linkage analysis of carotid artery traits in exceptionally long-lived families.

ABSTRACT:

Background and aims

Atherosclerosis develops with age and is partially controlled by genetics. Research to date has identified common variants with small effects on atherosclerosis related traits. We aimed to use family-based genome-wide linkage analysis to identify chromosomal regions potentially harboring rare variants with larger effects for atherosclerosis related traits.

Methods

Participants included 2205 individuals from the Long Life Family Study (LLFS), which recruited families with exceptional longevity from Boston, New York, Pittsburgh, and Denmark. Participants underwent B-mode ultrasonography of the carotid arteries to measure intima-media thickness (IMT), inter-adventitial diameter (IAD), and plaque presence and severity. We conducted residual heritability and g

SUBMITTER: Kuipers AL 

PROVIDER: S-EPMC6899182 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature