Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents.

ABSTRACT:

Objective

Cocaine use disorders (CUDs) represent a major public health problem in many countries. To better understand the interaction between the environmental modulations and phenotype, the aim of the present study was to investigate the DNA methylation pattern of CUD patients, who had concomitant cocaine and crack dependence, and healthy controls.

Methods

We studied DNA methylation profiles in the peripheral blood of 23 CUD patients and 24 healthy control subjects using the Illumina Infinium HumanMethylation450 BeadChip arrays.

Results

Comparison between CUD patients and controls revealed 186 differentially methylated positions (DMPs; adjusted p-value [adjP] < 10-5) related to 152 genes, with a subset of CpGs confirmed by pyrosequencing. DNA methylation patterns di

SUBMITTER: Camilo C 

PROVIDER: S-EPMC6899365 | biostudies-literature | 2019 Nov-Dec

REPOSITORIES: biostudies-literature