SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.

ABSTRACT: GABA_A receptors mediate fast inhibitory transmission in the brain, and their number can be rapidly up- or downregulated to alter synaptic strength. Neuroligin-2 plays a critical role in the stabilization of synaptic GABA_A receptors and the development and maintenance of inhibitory synapses. To date, little is known about how the amount of neuroligin-2 at the synapse is regulated and whether neuroligin-2 trafficking affects inhibitory signaling. Here, we show that neuroligin-2, when internalized to endosomes, co-localizes with SNX27, a brain-enriched cargo-adaptor protein that facilitates membrane protein recycling. Direct interaction between the PDZ domain of SNX27 and PDZ-binding motif in neuroligin-2 enables membrane retrieval of neuroligin-2, thus enhancing synapti

SUBMITTER: Halff EF 

PROVIDER: S-EPMC6899438 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature