Guiding Therapy by Coronary CT Angiography Improves Outcomes in Patients With Stable Chest Pain.

ABSTRACT:

Background

Within the SCOT-HEART (Scottish COmputed Tomography of the HEART Trial) trial of patients with stable chest pain, the use of coronary computed tomography angiography (CTA) reduced the rate of death from coronary heart disease or nonfatal myocardial infarction (primary endpoint).

Objectives

This study sought to assess the consistency and mechanisms of the 5-year reduction in this endpoint.

Methods

In this open-label trial, 4,146 participants were randomized to standard care alone or standard care plus coronary CTA. This study explored the primary endpoint by symptoms, diagnosis, coronary revascularizations, and preventative therapies.

Results

Event reductions were consistent across symptom and risk categories (p = NS for interactions). In patients who

SUBMITTER: Adamson PD 

PROVIDER: S-EPMC6899446 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature