Differential associations of allergic disease genetic variants with developmental profiles of eczema, wheeze and rhinitis.

ABSTRACT:

Background

Allergic diseases (eczema, wheeze and rhinitis) in children often present as heterogeneous phenotypes. Understanding genetic associations of specific patterns of symptoms might facilitate understanding of the underlying biological mechanisms.

Objective

To examine associations between allergic disease-related variants identified in a recent genome-wide association study and latent classes of allergic diseases (LCADs) in two population-based birth cohorts.

Methods

Eight previously defined LCADs between birth and 11 years: "No disease," "Atopic march," "Persistent eczema and wheeze," "Persistent eczema with later-onset rhinitis," "Persistent wheeze with later-onset rhinitis," "Transient wheeze," "Eczema only" and "Rhinitis only" were used as the study outcome.

SUBMITTER: Clark H 

PROVIDER: S-EPMC6899469 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature