Tailored Transition-Metal Coordination Environments in Imidazole-Modified DNA G-Quadruplexes.

ABSTRACT: Two types of imidazole ligands were introduced both at the end of tetramolecular and into the loop region of unimolecular DNA G-quadruplexes. The modified oligonucleotides were shown to complex a range of different transition-metal cations including Ni^II , Cu^II , Zn^II and Co^II , as indicated by UV/Vis absorption spectroscopy and ion mobility mass spectrometry. Molecular dynamics simulations were performed to obtain structural insight into the investigated systems. Variation of ligand number and position in the loop region of unimolecular sequences derived from the human telomer region (htel) allows for a controlled design of distinct coordination environments with fine-tuned metal affinities. It is shown that Cu^II , which is typically

SUBMITTER: Punt PM 

PROVIDER: S-EPMC6899475 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature