FORWARD Study: Evaluating the Comparative Effectiveness of OnabotulinumtoxinA and Topiramate for Headache Prevention in Adults With Chronic Migraine.

ABSTRACT:

Objective

To compare effectiveness of onabotulinumtoxinA and topiramate for chronic migraine (CM) prevention.

Background

The efficacy* of onabotulinumtoxinA and topiramate has been established in placebo-controlled randomized clinical trials (*defined as the benefit of treatment under ideal conditions). The effectiveness* of the 2 preventive treatments, however, has not been established (*the benefit of treatment under real-world conditions, representing a blend of efficacy and tolerability).

Methods

In this multicenter, randomized, parallel-group, post-authorization, open-label prospective study (FORWARD; ClinicalTrials.gov, NCT02191579), we randomized adults with CM (1:1) to onabotulinumtoxinA 155 U every 12 weeks for 3 cycles or topiramate "immediate release" 50-10

SUBMITTER: Rothrock JF 

PROVIDER: S-EPMC6899480 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature