Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes.

ABSTRACT: Some viruses are released from cells as pools of membrane-associated virions. By increasing the multiplicity of infection (MOI), this type of collective dispersal could favor viral cooperation, but also the emergence of cheater-like viruses such as defective interfering particles. To better understand this process, we examined the genetic diversity of membrane-associated coxsackievirus infectious units. We find that infected cells release membranous structures (including vesicles) that contain 8-21 infectious particles on average. However, in most cases (62%-93%), these structures do not promote the co-transmission of different viral genetic variants present in a cell. Furthermore, collective dispersal has no effect on viral population sequence diversity. Our results indicate that membrane

SUBMITTER: Bou JV 

PROVIDER: S-EPMC6899498 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature