Ontology highlight
ABSTRACT:
SUBMITTER: Srivastava S
PROVIDER: S-EPMC6899513 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Cell reports 20191001 1
The glucocorticoid receptor (GR) acts as a ubiquitous cortisol-dependent transcription factor (TF). To identify co-factors, we used protein-fragment complementation assays and found that GR recognizes FLI1 and additional ETS family proteins, TFs relaying proliferation and/or migration signals. Following steroid-dependent translocation of FLI1 and GR to the nucleus, the FLI1-specific domain (FLS) binds with GR and strongly enhances GR's transcriptional activity. This interaction has functional co ...[more]