Effects of the sodium-glucose co-transporter-2 inhibitor dapagliflozin on estimated plasma volume in patients with type 2 diabetes.

ABSTRACT:

Aims

To compare the effects of the sodium-glucose co-transporter-2 (SGLT2) inhibitor dapagliflozin on estimated (ePV) and measured plasma volume (mPV) and to characterize the effects of dapagliflozin on ePV in a broad population of patients with type 2 diabetes.

Materials and methods

The Strauss formula was used to calculate changes in ePV. Change in plasma volume measured with ¹²⁵ I-human serum albumin (mPV) was compared with change in ePV in 10 patients with type 2 diabetes randomized to dapagliflozin 10 mg/d or placebo. Subsequently, changes in ePV were measured in a pooled database of 13 phase 2b/3 placebo-controlled clinical trials involving 4533 patients with type 2 diabetes who were randomized to dapagliflozin 10 mg daily or matched placebo.

Results

SUBMITTER: Dekkers CCJ 

PROVIDER: S-EPMC6899523 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature