Association of multiple candidate genes with mild cognitive impairment in an elderly Chinese Uygur population in Xinjiang.

ABSTRACT:

Background

Mild cognitive impairment (MCI) is a high-risk factor for Alzheimer's disease (AD). In the present study, we investigated the association of genetic polymorphisms of five genes (8-oxoguanine DNA glycosylase 1 (OGG1), bridging integrator 1 (BIN1), sortilin-related receptor 1 (SORL1), presenilin 2 (PSEN2) and nerve growth factor (NGF)) with MCI risk in a Xinjiang Uygur population. We also tested the relationship between the promoter methylation of genes OGG1 and dihydrolipoamide S-succinyltransferase (DLST) with MCI.

Methods

This study involved 43 MCI patients and 125 controls. Genotyping was done by Sanger sequencing. DNA methylation assays used quantitative methylation-specific polymerase chain reaction.

Results

We found that polymorphisms of five genes and

SUBMITTER: Zou T 

PROVIDER: S-EPMC6899574 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature