Design and testing of microbubble-based MRI contrast agents for gastric pressure measurement.

ABSTRACT:

Purpose

This work demonstrates specifically tailored microbubble-based preparations and their suitability as MRI contrast agents for ingestion and measuring temporal and spatial pressure variation in the human stomach.

Methods

Enhanced alginate spheres were prepared by incorporating gas-filled microbubbles into sodium alginate solution followed by the polymerization of the mixture in an aqueous calcium lactate solution. The microbubbles were prepared with a phospholipid shell and perfluorocarbon gas filling, using a mechanical cavitational agitation regime. The NMR signal changes to externally applied pressure and coming from the enhanced alginate spheres were acquired and compared with that of alginate spheres without microbubbles. In vivo investigations were also carried o

SUBMITTER: Abdurakman E 

PROVIDER: S-EPMC6899603 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature