Enzymatic quantification of total serum bile acids as a monitoring strategy for women with intrahepatic cholestasis of pregnancy receiving ursodeoxycholic acid treatment: a cohort study.

ABSTRACT:

Objective

To evaluate enzymatic total serum bile acid quantification as a monitoring strategy for women with intrahepatic cholestasis of pregnancy (ICP) treated with ursodeoxycholic acid (UDCA).

Design

Cohort.

Setting

One UK university hospital.

Population

29 ICP cases treated with UDCA.

Methods

Serial samples were collected prospectively throughout gestation. Total serum bile acids were measured enzymatically and individual bile acids by high-performance liquid chromatography-tandem mass spectrometry. Data were log-transformed and analysed with random effects generalised least square regression.

Main outcome measures

The relationship between enzymatic total bile acid measurements and individual bile acid concentrations after UDCA treatment.

Re

SUBMITTER: Manna LB 

PROVIDER: S-EPMC6899621 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature