Cyclic vomiting syndrome: Pathophysiology, comorbidities, and future research directions.

ABSTRACT: Cyclic vomiting syndrome (CVS) is characterized by severe episodic emesis in adults and children. Cannabinoid hyperemesis syndrome is an increasingly recognized CVS-like illness that has been associated with chronic cannabis use. There are significant gaps in our understanding of the pathophysiology, clinical features, comorbidities, and effective management options of CVS. Recommendations for treating CVS are based on limited clinical data, as no placebo-controlled, randomized trials have yet been conducted. Diseases associated with CVS, including migraine, mitochondrial disorders, autonomic dysfunction, and psychiatric comorbidities, provide clues about pathophysiologic mechanisms and suggest potential therapies. We review our current understanding of CVS and propose future research dire

SUBMITTER: Hasler WL 

PROVIDER: S-EPMC6899706 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature