Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis.

ABSTRACT:

Background

Single-centre studies reported alterations of faecal microbiota in patients with primary sclerosing cholangitis (PSC). As regional factors may affect microbial communities, it is unclear if a microbial signature of PSC exists across different geographical regions.

Aim

To identify a robust microbial signature of PSC independent of geography and environmental influences.

Methods

We included 388 individuals (median age, 47 years; range, 15-78) from Germany and Norway in the study, 137 patients with PSC (n = 75 with colitis), 118 with ulcerative colitis (UC) and 133 healthy controls. Faecal microbiomes were analysed by 16S rRNA gene sequencing (V1-V2). Differences in relative abundances of single taxa were subjected to a meta-analysis.

Results

In both co

SUBMITTER: Ruhlemann M 

PROVIDER: S-EPMC6899739 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature