[¹⁸ F]-Sodium Fluoride PET/MR Imaging for Bone-Cartilage Interactions in Hip Osteoarthritis: A Feasibility Study.

ABSTRACT: This study characterized the distribution of [¹⁸ F]-sodium fluoride (NaF) uptake and blood flow in the femur and acetabulum in hip osteoarthritis (OA) patients to find associations between bone remodeling and cartilage composition in the presence of morphological abnormalities using simultaneous positron emission tomography and magnetic resonance imaging (PET/MR), quantitative magnetic resonance imaging (MRI) and femur shape modeling. Ten patients underwent a [¹⁸ F]-NaF PET/MR dynamic scan of the hip simultaneously with: (i) fast spin-echo CUBE for morphology grading and (ii) T_1ρ /T₂ magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots for cartilage, bone segmentation, bone shape modeling, and T_1ρ

SUBMITTER: Tibrewala R 

PROVIDER: S-EPMC6899769 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature