Weighted gene coexpression network analysis reveals hub genes involved in cholangiocarcinoma progression and prognosis.

ABSTRACT:

Aim

Cholangiocarcinoma (CCA) is a highly malignant tumor found in the bile duct epithelial cells, and the second most common primary tumor of the liver. However, the pivotal roles of molecular biomarkers in oncogenesis of CCA are unclear. Therefore, we aim to explore the underlying mechanisms of progression and screen for novel prognostic biomarkers and treatment targets.

Method

The data of mRNA sequencing and clinical information of CCA patients in The Cancer Genome Atlas was analyzed by weighted gene coexpression network analysis (WGCNA). Modules and clinical traits were constructed according to Pearson's correlation analysis, and Gene Ontology and pathway enrichment analysis were applied. Hub genes of these modules were screened by intramodule analysis; Cytoscape with Sea

SUBMITTER: Tian A 

PROVIDER: S-EPMC6899837 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature