GDF-15 in solid vs non-solid treatment-naive malignancies.

ABSTRACT:

Aim

GDF-15 is an established cardiovascular risk marker but is equally implicated in tumour biology. Elevated levels of GDF-15 have indeed been observed in distinct tumour entities. This study aimed to explore the relation of GDF-15 to other cardiac biomarkers and the general association of GDF-15 on prognosis in an unselected cohort of treatment-naïve cancer patients.

Methods

We prospectively enrolled 555 consecutive patients at time of diagnosis of malignant disease prior receiving anticancer therapy. Plasma GDF-15 concentrations were determined alongside other cardiac and routine laboratory markers. All-cause mortality was defined as primary endpoint.

Results

GDF-15 levels were 338 ng/L (IQR:205-534) for the total cohort, and values were comparable for different tu

SUBMITTER: Arfsten H 

PROVIDER: S-EPMC6899906 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature