Adverse events related to low dose corticosteroids in autoimmune hepatitis.

ABSTRACT:

Background

Autoimmune hepatitis requires long-term therapy, and systemic corticosteroids are the backbone of therapeutic management. Prolonged use of corticosteroids may lead to adverse events but data from long-term studies are mainly derived from studies in rheumatic diseases.

Aim

To assess cataract, diabetes and fractures in relation to corticosteroid doses in the long-term maintenance treatment of patients with autoimmune hepatitis.

Methods

We retrospectively collected data on 476 patients (77% women) with an established diagnosis of autoimmune hepatitis. Binary logistic regression with a generalised estimating equation was used to analyse the association between current corticosteroid use and the incidence of cataract, diabetes and fractures with onset after auto

SUBMITTER: van den Brand FF 

PROVIDER: S-EPMC6899908 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature