Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging.

ABSTRACT:

Objective

To investigate the multifactorial processes underlying cognitive aging based on the hypothesis that multiple causal pathways and mechanisms (amyloid, vascular, and resilience) influence longitudinal cognitive decline in each individual through worsening brain health.

Methods

We identified 1,230 elderly subjects (aged ≥50 years) with an average of 4.9 years of clinical follow-up and with amyloid positron emission tomography, diffusion tensor imaging, and structural magnetic resonance imaging scans from the population-based Mayo Clinic Study of Aging. We examined imaging markers of amyloid and brain health (white matter microstructural integrity and cortical thinning), systemic vascular health preceding the imaging markers, and early to midlife intellectual enrichmen

SUBMITTER: Vemuri P 

PROVIDER: S-EPMC6899909 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature