Body composition in anorexia nervosa: Meta-analysis and meta-regression of cross-sectional and longitudinal studies.

ABSTRACT:

Objective

Clinically, anorexia nervosa (AN) presents with altered body composition. We quantified these alterations and evaluated their relationships with metabolites and hormones in patients with AN longitudinally.

Method

In accordance with PRISMA guidelines, we conducted 94 meta-analyses on 62 samples published during 1996-2019, comparing up to 2,319 pretreatment, posttreatment, and weight-recovered female patients with AN with up to 1,879 controls. Primary outcomes were fat mass, fat-free mass, body fat percentage, and their regional distribution. Secondary outcomes were bone mineral density, metabolites, and hormones. Meta-regressions examined relationships among those measures and moderators.

Results

Pretreatment female patients with AN evidenced 50% lower fat ma

SUBMITTER: Hubel C 

PROVIDER: S-EPMC6899925 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature