IL-10 from plasmacytoid dendritic cells promotes angiogenesis in the early stage of endometriosis.

ABSTRACT: An elevated level of IL-10 has been considered a critical factor for the development of endometriosis; however, its detailed mechanism and causal relationship remain unclear. This study explored the cellular source and angiogenic activity of local IL-10 during the early stage of endometriosis. Using a surgical murine model, we found that localised treatment with exogenous recombinant IL-10 on the day of surgery significantly enhanced endometriotic lesion growth and angiogenesis, whereas blocking local IL-10 activity using mAbs significantly suppressed those effects. Adoptive transfer of Il10^+/+ plasmacytoid dendritic cells into mice significantly enhanced lesion development, whereas Il10^-/- plasmacytoid dendritic cells significantly inhibited lesion development. Furth

SUBMITTER: Suen JL 

PROVIDER: S-EPMC6899974 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature