The mitochondrial NAD⁺ transporter (NDT1) plays important roles in cellular NAD⁺ homeostasis in Arabidopsis thaliana.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺ ) is an essential coenzyme required for all living organisms. In eukaryotic cells, the final step of NAD⁺ biosynthesis is exclusively cytosolic. Hence, NAD⁺ must be imported into organelles to support their metabolic functions. Three NAD⁺ transporters belonging to the mitochondrial carrier family (MCF) have been biochemically characterized in plants. AtNDT1 (At2g47490), focus of the current study, AtNDT2 (At1g25380), targeted to the inner mitochondrial membrane, and AtPXN (At2g39970), located in the peroxisomal membrane. Although AtNDT1 was presumed to reside in the chloroplast membrane, subcellular localization experiments with green fluorescent protein (GFP) fusions revealed that AtNDT1 locates exclusivel

SUBMITTER: de Souza Chaves I 

PROVIDER: S-EPMC6900047 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature