Ontology highlight
ABSTRACT:
SUBMITTER: Kremer L
PROVIDER: S-EPMC6900058 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20191004 46
The Hedgehog (Hh) signaling pathway is crucial for vertebrate embryonic development, tissue homeostasis and regeneration. Hh signaling is upregulated in basal cell carcinoma and medulloblastoma and Hh pathway inhibitors targeting the Smoothened (SMO) protein are in clinical use. However, the signaling cascade is incompletely understood and novel druggable proteins in the pathway are in high demand. We describe the discovery of the Hh-pathway modulator Pipinib by means of cell-based screening. Ta ...[more]