Photochemical Asymmetric Nickel-Catalyzed Acyl Cross-Coupling.

ABSTRACT: Photochemical enantioselective nickel-catalyzed cross-coupling reactions are difficult to implement. We report a visible-light-mediated strategy that successfully couples symmetrical anhydrides and 4-alkyl dihydropyridines (DHPs) to afford enantioenriched α-substituted ketones under mild conditions. The chemistry does not require exogenous photocatalysts. It is triggered by the direct excitation of DHPs, which act as a radical source and as a reductant, facilitating the turnover of the chiral catalytic nickel complex.

SUBMITTER: Gandolfo E 

PROVIDER: S-EPMC6900114 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature