Maternal cognitive function during pregnancy in relation to hypo- and hyperthyroxinemia.

ABSTRACT:

Objective

To assess a possible relationship between maternal cognitive dysfunction during pregnancy and hypothyroxinemia, adjusted for major confounders.

Background

Thyroid dysfunction in general is associated with cognitive dysfunction. Cognitive dysfunction is common during pregnancy.

Design

Prospective follow-up study from 12 to 32 weeks of pregnancy.

Participants

2082 healthy pregnant women.

Measurements

Cognitive function, depression and sleeping problems were assessed by self-report questionnaires at 12, 22 and 32 weeks of gestation, higher scores reflecting more symptoms. FT4, TSH and TPO-Ab were assessed at 12 weeks of gestation.

Definitions

healthy (euthyroxinemia) control group: FT4 within 10-90th percentiles, without elevated TPO-Ab tit

SUBMITTER: Pop VJ 

PROVIDER: S-EPMC6900117 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature