β-adrenergic modulation of discrimination learning and memory in the auditory cortex.

ABSTRACT: Despite vast literature on catecholaminergic neuromodulation of auditory cortex functioning in general, knowledge about its role for long-term memory formation is scarce. Our previous pharmacological studies on cortex-dependent frequency-modulated tone-sweep discrimination learning of Mongolian gerbils showed that auditory-cortical D_1/5 -dopamine receptor activity facilitates memory consolidation and anterograde memory formation. Considering overlapping functions of D_1/5 -dopamine receptors and β-adrenoceptors, we hypothesised a role of β-adrenergic signalling in the auditory cortex for sweep discrimination learning and memory. Supporting this hypothesis, the β_1/2 -adrenoceptor antagonist propranolol bilaterally applied to the gerbil auditory cortex after t

SUBMITTER: Schicknick H 

PROVIDER: S-EPMC6900137 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature