The expression of human leukocyte antigen by human ejaculated spermatozoa.

ABSTRACT:

Background

After coitus and insemination, an inflammatory response is evident in the female reproductive tract (FRT). Semen contains a variety of immune-activating components that have a major role in the induction of an immune response in the FRT. One of the most important is (human leukocyte antigen) HLA molecules which are present in soluble form in seminal plasma and in membrane form on the surface of cells (such as epithelial and leukocytes) existing in semen. Nevertheless, there is considerable debate over the expression of HLA antigens by human spermatozoa. Considering the critical role of HLA molecules in reproduction and the induction of an immune response, it is very important to clearly define HLA expression by spermatozoa and the role of these molecules in sperm morphol

SUBMITTER: Sereshki N 

PROVIDER: S-EPMC6900355 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature