Effects of early trauma and corticotropin-releasing factor receptor 1 gene polymorphism on adult visual spatial memory.

ABSTRACT:

Background

The study sought to determine the effects of earthquake on the working memory of adults who experienced earthquake either as infants or fetuses and also investigates whether earthquake exposure and corticotropin-releasing factor receptor 1 (CRHR1) variants rs242924 and rs7209436 interacted with each other in modulating working memory.

Methods

We enrolled subjects who experienced the Tangshan Earthquake as fetuses (group I) or infants (group II), as well as those who did not experience the earthquake (group III). Their working memory was measured using Brief Visuospatial Memory Test-Revised (BVMT-R) and Hopkins Verbal Learning Test-Revised (HVLT-R). Two single-nucleotide polymorphisms (SNPs) of CRHR1 rs242924 and rs7209436 were analyzed by fluorescence quantitative

SUBMITTER: Sun FF 

PROVIDER: S-EPMC6900365 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature