Polymorphisms of CHRNA3 and CHRNA5: Head and neck cancer and cigarette consumption intensity in a Brazilian population.

ABSTRACT:

Background

Cigarette consumption has been identified as the main non-etiological factor in head and neck cancer (HNC) development. One of the main compounds in cigarettes is nicotine, which binds directly to nicotine acetylcholine receptors (nAchRs) in the body, which are encoded by different genes of the CHRNA family. Polymorphisms in some of these genes have been studied in relation to the risk of HNC and cigarette consumption intensity. The aim of this study was to evaluate whether there were associations between the CHRNA3 (rs578776) and CHRNA5 (rs16969968) polymorphisms and HNC risk and between the polymorphisms and the intensity of cigarette consumption.

Methods

A total of 1,067 individuals from Heliopolis Hospital in São Paulo were investigated, including 619 patients

SUBMITTER: Silva MR 

PROVIDER: S-EPMC6900374 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature