Reference intervals for lymphocyte subsets in preterm and term neonates without immune defects.

ABSTRACT:

Background

In 6.5 years of newborn screening for severe combined immunodeficiency in California, 3,252,156 infants had DNA from dried blood spots (DBSs) assayed for T-cell receptor excision circles. Infants with T-cell receptor excision circle values of less than a designated cutoff on a single DBS, 2 DBS samples with insufficient PCR amplification, or known genetic risk of immunodeficiency had peripheral blood complete blood counts and lymphocyte subsets assayed in a single flow cytometry laboratory. Cases in which immune defects were ruled out were available for analysis.

Objective

We sought to determine reference intervals for lymphocyte subsets in racially/ethnically diverse preterm and term newborns who proved to be unaffected by any T-lymphopenic immune disorder.

Me

SUBMITTER: Amatuni GS 

PROVIDER: S-EPMC6900445 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature